Nonetheless, when criterion Ib is fulfilled along with the charge imbalance exceeds the estimated analytical uncertainty, the effects needs to be very carefully interpreted, as explained by Steiger and Heritage32. The analysis is dependent on the precise analytical technique, and just one should decide In the event the contribution of the anions in excessive is very important as compared to the entire charge imbalance, even though thinking of the analytical uncertainty, this analysis is performed in the complex validation area.
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